Syntheses of spliceostatins and thailanstatins: a review

• William A. Donaldson

Beilstein J. Org. Chem. 2020, 16, 1991–2006, doi:10.3762/bjoc.16.166

• (Figure 1) are a family of linear peptide/polyketide natural products isolated from the bacteria Burkholderia sp. FERM BP-3421 [1][2][3] (originally identified as Pseudomonas sp. No 2663) and Burkholderia sp. MSMB 43 [4][5]. These compounds are of interest due to their ability to bind to a subunit of the

4-Hydroxy-3-methyl-2(1H)-quinolone, originally discovered from a Brassicaceae plant, produced by a soil bacterium of the genus Burkholderia sp.: determination of a preferred tautomer and antioxidant activity

• Dandan Li,
• Naoya Oku,
• Yukiko Shinozaki,
• Yoichi Kurokawa and
• Yasuhiro Igarashi

Beilstein J. Org. Chem. 2020, 16, 1489–1494, doi:10.3762/bjoc.16.124

• providing sufficient evidence to support the structure, was isolated from a fermentation extract of Burkholderia sp. 3Y-MMP isolated from a soil by a Zn2+ enrichment culture. Detailed spectroscopic analyses by MS and NMR, combined with 13C chemical shift comparison with literature values of the related

• in the host organisms. Keywords: antioxidant; Burkholderia sp; quinolone; soil bacterium; Zn2+ enrichment culture; Findings 4-Hydroxy-2(1H)-quinolone (3) is a unique structural motif mostly found in alkaloids from rutaceous plants (family Rutaceae) [1][2]. This motif has several tautomeric forms

• secondary metabolism [15]. In the course of our continuing studies on bioactive metabolites of less studied bacterial taxa [16], Burkholderia sp. 3Y-MMP, isolated from soil by an exhaustive enrichment culture under Zn2+-load, was selected for a detailed chemical study, which resulted in the isolation of 4

Two new 2-alkylquinolones, inhibitory to the fish skin ulcer pathogen Tenacibaculum maritimum, produced by a rhizobacterium of the genus Burkholderia sp.

• Dandan Li,
• Naoya Oku,
• Atsumi Hasada,
• Masafumi Shimizu and
• Yasuhiro Igarashi

Beilstein J. Org. Chem. 2018, 14, 1446–1451, doi:10.3762/bjoc.14.122

• a culture of strain MBAF1239, isolated from a rhizosphere of Welsh onion (Allium fistulosum). A 16S rDNA sequence analysis identified MBAF1239 as Burkholderia sp. within the B. cepacia complex (DDBJ accession number LC194190). Fermentation, extraction, and isolation Burkholderia sp. MBAF1239 was